Thunder God Vine (Tripterygium wilfordii)

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Thunder God Vine

雷公藤 (Léi Gōng Téng) · Tripterygium wilfordii

A powerful TCM herb for autoimmune conditions and rheumatoid arthritis. Contains triptolide — potent but toxic. Used in Chinese hospitals under supervision. NOT for self-medication.

Evidence Score
8/10
Good Evidence
Safety
Significant risks

Good For

Key Benefits

May help reduce inflammation and joint discomfort

Traditionally used to support mobility and ease pain

May support immune system function

Traditionally used to strengthen defensive qi and resistance to illness

How to Take

Typical dose: Follow product label directions. Typical range: 500-1500mg daily as standardized extract
Forms: capsule, powder, tea/decoction
Timing: Take with food unless otherwise directed. Allow 2-4 weeks for full effects with tonic herbs
Start with lower doses and increase gradually. Quality and standardization vary between brands.

Safety & Interactions

Possible Side Effects

  • Significant side effects possible even at normal doses
  • Liver toxicity reported in some cases
  • Narrow therapeutic window — dose-dependent toxicity

Do Not Use If

  • Do not self-medicate — professional supervision required
  • Pregnancy and breastfeeding — strictly avoid
  • Liver or kidney disease
  • Children

Drug Interactions

  • Multiple serious drug interactions possible
  • May dangerously potentiate blood thinners, immunosuppressants, or sedatives
  • Must inform doctor before use

Traditional Use

In Traditional Chinese Medicine, 雷公藤 (Léi Gōng Téng) has been used for centuries. TCM practitioners use it to reinforce the body's defensive energy (wei qi). TCM practitioners use it to expel wind-dampness and strengthen the sinews and bones.

Modern Research

This herb has extensive scientific backing with hundreds of published studies. Multiple clinical trials support its traditional uses, and active compounds have been well-characterized. It represents one of the more evidence-based options in the herbal pharmacopoeia.

View all studies on PubMed for Tripterygium wilfordii

Where to Buy

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