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St. John's Wort
贯叶连翘 (Guàn Yè Lián Qiáo) · Hypericum perforatum
The most studied herb for mild-moderate depression — comparable to SSRIs in multiple meta-analyses. Contains hypericin and hyperforin. Significant drug interactions limit use.
Good For
Key Benefits
May help the body adapt to stress
Traditionally used to calm the spirit and ease tension
How to Take
Safety & Interactions
Possible Side Effects
- Digestive discomfort at higher doses
- May cause drowsiness or stimulation depending on the herb
- Allergic reactions possible in sensitive individuals
Do Not Use If
- Pregnancy and breastfeeding (insufficient safety data)
- Children under 12 without professional guidance
- Scheduled surgery (stop 2 weeks before)
Drug Interactions
- May interact with prescription medications
- May affect blood sugar or blood pressure medications
- Consult pharmacist before combining with other supplements
Traditional Use
In Traditional Chinese Medicine, 贯叶连翘 (Guàn Yè Lián Qiáo) has been used for centuries. It is traditionally used to calm the spirit (shen) and settle the heart-mind.
Modern Research
This herb has extensive scientific backing with hundreds of published studies. Multiple clinical trials support its traditional uses, and active compounds have been well-characterized. It represents one of the more evidence-based options in the herbal pharmacopoeia.
View all studies on PubMed for Hypericum perforatum →Where to Buy
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