Ginkgo Biloba (Ginkgo biloba)

Image: Wikimedia Commons, CC BY-SA

Ginkgo Biloba

铢杏 (YΓ­n XΓ¬ng) Β· Ginkgo biloba

One of the oldest living tree species. Widely studied for improving blood circulation to the brain, supporting memory, and protecting against cognitive decline.

Evidence Score
10/10
Strong Evidence
Safety
Use with caution

Good For

Key Benefits

Improves blood circulation to the brain

Established mechanism β€” increases cerebral blood flow in clinical imaging studies

May slow cognitive decline in dementia

Large trials (GEM, GuidAge) show modest benefit for existing cognitive impairment

Reduces symptoms of peripheral artery disease

Meta-analysis shows improved walking distance in intermittent claudication

May help tinnitus and vertigo

Some positive trials though overall evidence is mixed

How to Take

Typical dose: 120-240mg standardized extract daily (EGb 761 β€” 24% flavone glycosides, 6% terpene lactones)
Forms: standardized extract capsule, tablet, liquid extract
Timing: Split into 2-3 doses. Effects take 4-6 weeks to appear. Use the standardized extract β€” raw leaf tea is less effective and potentially toxic
EGb 761 is the specific extract used in most clinical trials (Tanakan/Tebonin brand)

Safety & Interactions

Possible Side Effects

  • Headache
  • Digestive upset
  • Dizziness
  • Allergic skin reactions (rare)

Do Not Use If

  • Bleeding disorders
  • 2 weeks before surgery
  • Seizure disorders (may lower threshold)

Drug Interactions

  • Blood thinners (warfarin, aspirin, NSAIDs) β€” increased bleeding risk
  • Anticonvulsants β€” may reduce effectiveness
  • SSRIs β€” rare reports of serotonin syndrome
  • Diabetes medications β€” may affect blood sugar

Traditional Use

The ginkgo tree is a living fossil β€” 270 million years old. In TCM, the seed (Bai Guo) is used more than the leaf. Seeds astringe the lungs, stop wheezing, and reduce vaginal discharge. The leaf extract is primarily a modern Western application developed from the 1960s onward.

Modern Research

Over 5,700 studies. The most studied herbal supplement for cognitive function. Active compounds: ginkgolides (PAF antagonists improving circulation) and bilobalide (neuroprotective). Evidence is strongest for existing cognitive impairment rather than prevention in healthy adults.

View all studies on PubMed for Ginkgo biloba β†’

Where to Buy

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